I was having issues with Windows XP clients not able to open xls, bmp, etc files on a volume that had been deduped. Windows 7 clients had no issue at all. It ended up being tracked back to enableecp registry entry
Very last post talks about enableecp and vipre
This article describes what the enableecp key does.
https://support.microsoft.com/en-us/kb/2817216
I was able to change HKLM\System\CurrentControlSet\Services\LanmanServer\Parameters\enableecp to 0 on the file server and restarted the server service and now the XP client isn’t getting any error messages on opening up files.
Note: This key is not on server 2012 by default .